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Generate single title from this title How AI is shortening drug discovery timelines in China in 100 -150 characters. And it must return only title i dont want any extra information or introductory text with title e.g: ” Here is a single title:”

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Insilico Medicine has reduced the time needed to produce some drug development candidates to about one year by combining artificial intelligence with laboratory research in China, according to CEO Alex Zhavoronkov.

The Hong Kong-listed company’s fastest programme reached candidate nomination in nine months, while its typical timeline is about 13 months, Zhavoronkov said. He said conventional approaches usually take about four-and-a-half years to reach the same stage.

The timeline covers early discovery and candidate selection, rather than the full process of bringing a drug to market. Clinical trials, manufacturing, and regulatory review remain separate stages.

AI shortens candidate selection

Insilico uses generative AI to identify biological targets, design potential drug molecules, and assess which compounds should advance to laboratory testing.

The company said its programmes typically reach preclinical-candidate nomination within 12 to 18 months after researchers synthesise and test between 60 and 200 molecules. Its workflow combines AI-generated designs with researcher review and experimental validation.

Laboratory experiments remain necessary to confirm the biological activity and drug properties of compounds selected by the models. Insilico said its AI-supported process allows teams to reach candidate nomination after testing a smaller set of synthesised molecules, although it has not provided a direct comparison with equivalent programmes developed without AI.

Insilico said it has generated 31 preclinical candidates since 2021. Thirteen programmes have received investigational new drug clearances, allowing them to advance towards human studies, according to the company’s pipeline disclosures.

The company conducts AI research in Montreal and Abu Dhabi, while much of its experimental validation and laboratory scale-up work takes place in China. Its Shanghai facility has automated parts of biological sampling and compound screening.

Teams outside China develop and evaluate the company’s AI models, while researchers in Shanghai handle biological testing, screening, and scale-up.

Zhavoronkov attributed part of the shorter development cycle to China’s research infrastructure, operating costs, and regulatory environment. He said pharmaceutical companies with research laboratories in China can remove about two years from traditional candidate-development timelines.

China has expanded beyond manufacturing generic drug ingredients and now plays a larger role in developing new medicines. International drugmakers also work with Chinese laboratories, contract research organisations, clinical-trial centres, and biotechnology companies.

A Pfizer executive said clinical development in China could be conducted three times faster and at about half the cost of equivalent work in Europe. Drug candidates typically take five to seven years to reach the Chinese market, compared with at least eight to 10 years in Western markets, according to Reuters.

China introduced a 30-working-day review pathway in 2025 for eligible Class I innovative-drug clinical-trial applications. Applications requiring expert consultation or involving complex technical issues can be moved to a 60-working-day review period.

“We now compete with Chinese pharmaceutical companies on timelines, and with traditional biotechnology companies in the West on novelty,” Zhavoronkov said.

Insilico has entered research and development agreements with pharmaceutical companies including Eli Lilly and Japan’s Takeda.

The company and Taiwan-based Bora Pharmaceuticals also announced a proposed strategic alliance that could exceed $2.5 billion if definitive agreements are signed and the collaboration is fully implemented.

Although Insilico operates research facilities in China, Zhavoronkov said more than 90% of its revenue comes from Western pharmaceutical companies. He did not disclose how much revenue the company generates in China.

Western licensing agreements are more lucrative for Insilico because China’s national insurance system offers lower reimbursement rates for highly novel drugs, Zhavoronkov said.

The company also limits sales of most of its software within China because of geopolitical concerns, Zhavoronkov said. It plans to expand its research operations in Shanghai.

Rentosertib moves towards Phase III trials

Insilico announced and registered a Phase III trial of Rentosertib in July 2026. The oral drug is being studied for idiopathic pulmonary fibrosis, a disease that causes progressive scarring of the lungs.

The company used AI to identify the drug’s biological target and generate and optimise its molecular structure.

The Phase III study is designed to enrol 320 participants across 47 centres in China. It will compare Rentosertib with a placebo over 52 weeks, with the primary endpoint measuring the annual rate of decline in forced vital capacity, a standard measure of lung function.

The trial was listed as not yet recruiting when its ClinicalTrials.gov record was updated on July 7. Enrolment was expected to begin in August 2026, with primary completion estimated for October 2029.

Rentosertib previously completed a smaller Phase IIa study. The Phase III trial will test the treatment in a larger patient group over a longer period.

Candidate nomination remains an early development milestone. Drugs must still complete preclinical testing, human trials, manufacturing validation, and regulatory review before they can be approved for sale.

Industry data have not established whether AI-designed drugs are more likely to succeed in later-stage trials.

A 2024 analysis of AI-native biotechnology pipelines reported Phase I success rates of between 80% and 90%. The same study found a Phase II success rate of about 40%, broadly in line with the historical industry comparison used by the researchers.

The researchers said the number of Phase II programmes was too small to determine whether AI improves later-stage clinical success. The analysis was based on publicly reported pipelines and did not compare otherwise identical AI-supported and conventional drug programmes.

Insilico said it has produced 31 preclinical candidates and secured 13 investigational new drug clearances. Rentosertib is its first programme to reach the Phase III stage, while none of the company’s experimental medicines has received commercial approval.

Automation changes biotech roles

AI and laboratory robotics are also changing staffing requirements within Insilico.

Zhavoronkov estimated that the company could automate or displace about 40% of its software-side workforce. He did not describe the figure as an announced staff reduction or apply it to the biotechnology industry as a whole.

Insilico employs about 400 people. Laboratory scientists and software engineers are being retrained to manage AI evaluation systems, automated equipment, and robotics, Zhavoronkov said.

The retraining is focused on AI benchmarks and robotic systems as the company automates more research and software functions, he said.

(Photo by Julia Koblitz)

See also: Bristol Myers Squibb buys Nvidia AI system for drug discovery

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Generate single title from this title AgentWatch: Proactive AWS monitoring with ambient agents in 100 -150 characters. And it must return only title i dont want any extra information or introductory text with title e.g: ” Here is a single title:”

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AgentWatch delivers ambient AWS resource monitoring for your DevOps team, moving beyond the reactive cycle of managing Amazon CloudWatch alarms across multiple accounts. CloudWatch alarms trigger too late, AWS Lambda errors accumulate unnoticed, and Amazon Elastic Compute Cloud (Amazon EC2) performance degradation goes undetected until customers report problems. This leaves your team constantly firefighting rather than preventing issues. Every day, you manually check dashboards, triage CloudWatch alarms and investigate issues that have already impacted your users. You have metrics streaming in, logs accumulating across dozens of services, and alarms firing constantly but knowing what matters, when it matters, and what to do about it remains the real challenge.
This reactive monitoring approach creates operational challenges for your team. You’re context-switching between tools, piecing together incident stories from fragmented data sources, and spending hours on post-mortems for problems you could have prevented. By the time you understand what went wrong, your customers have already experienced degraded performance or outages. Your on-call engineers are burned out from alert fatigue, and your team’s productivity suffers as routine monitoring tasks consume time that should be spent on innovation. These challenges lead to missed service level agreement (SLA) targets, customer escalations, and a growing backlog of technical debt as your team focuses on firefighting rather than implementing preventive measures. Current monitoring tools require you to constantly query, analyze, and decide what deserves attention. You need a different approach. This is where AgentWatch, an ambient AWS resource monitoring agent, offers a different approach to infrastructure oversight. The agent works continuously alongside your team to observe your infrastructure, analyze patterns, and surface insights without requiring constant human intervention. It monitors your systems and brings you into the loop only when your judgment or action is truly needed.
In this post, we demonstrate the capabilities of AgentWatch through practical implementation. You will see how the solution performs infrastructure checks every 15 minutes, summarizing CloudWatch metrics, logs, and alarms across multiple AWS accounts. The agent delivers actionable reports directly to Slack and responds to natural language queries about your infrastructure state. Throughout, we explore three human-in-the-loop patterns that maintain appropriate oversight while maximizing automation.
What are ambient agents?
Ambient agents represent a shift toward event-driven, autonomous AI systems. These agents listen to event streams and respond dynamically, processing multiple events simultaneously while reducing human operational burden. They provide continuous monitoring without constant human intervention yet maintain appropriate oversight by involving humans at critical decision points.
Ambient agents can be triggered dynamically in an event-driven way and process multiple tasks in parallel, making them well suited for monitoring scenarios where conditions change rapidly and require continuous attention.Ambient agents work best for specific scenarios. Bringing them into your workflow involves thoughtful consideration of when and how these agents interact with humans and the control that humans have over the workflow as agents execute and notify end-users.
How does this apply to your AWS infrastructure?
For your AWS infrastructure, this means AgentWatch can continuously monitor your resources, identify trends, and deliver actionable intelligence without requiring you to manually query dashboards or sift through logs. Now that you understand the ambient agent concept, let’s explore how AgentWatch implements these principles for AWS infrastructure monitoring.
Introducing AgentWatch
We built AgentWatch as an ambient AWS monitoring agent on Amazon Bedrock’s large language model (LLM) and deploy it using Amazon Bedrock AgentCore Runtime—a secure, serverless hosting environment purpose-built for running AI agents at scale. With AgentCore Runtime, you can deploy agents as HTTP endpoints that you call programmatically. AgentCore Runtime handles authentication, scaling, and infrastructure management automatically so you can focus on agent capabilities rather than operational concerns.
AgentWatch demonstrates how you can implement intelligent infrastructure monitoring that balances automation with human control. We’re building a hybrid ambient agent some tasks it performs are fully autonomous (low-risk activities like monitoring resource utilization and providing information), while other actions require user configuration and approval, such as analyzing alarm causes and implementing fixes.
Your organization might use different communication tools for collaboration. As AI capabilities advance, you will work differently with autonomous workers (or agents) across various communication services like Slack. These agents accomplish tasks faster and more efficiently while maintaining a tighter feedback loop with end users. For this solution, we use Slack as the end-user interface where the ambient agent posts messages and where you interact with the agent on demand.
With this foundation in place, let’s examine how AgentWatch maintains appropriate human oversight through three core patterns.
Human-in-the-loop patterns
Human-in-the-loop (HITL) is fundamental for building trustworthy ambient agents. While ambient agents operate autonomously, they must know when to involve humans in their decision-making process. AgentWatch implements three core HITL patterns that balance autonomy with appropriate human oversight:

Notify Pattern: The notify pattern alerts you about important events without taking action. This is useful for flagging events you should be aware of, but where the agent is not empowered to act.

Implementation: Every 15 minutes (parameterized, MonitoringSchedule rate controls the rate; other options are to run it at 5, 10, 30, 60 mins intervals), AgentWatch generates a monitoring report covering CloudWatch alarms, critical issues, and resource health across AWS services. The agent posts these reports to a Slack channel, keeping your team informed without requiring immediate action or approval. We chose 15-minute intervals to balance timely detection of issues with reasonable API usage and notification frequency. This is short enough to catch problems quickly but long enough to avoid alert fatigue.

Question Pattern: The question pattern allows the agent to ask you for clarification when it encounters uncertainty about how to proceed. This helps prevent the agent from making incorrect assumptions or taking inappropriate actions when faced with ambiguous situations.

Implementation: If AgentWatch detects a critical alarm but is unclear whether to proceed with automated remediation or escalation to an on-call engineer, it posts a question to Slack asking for guidance. This mimics how a site reliability engineer (SRE) would consult with a senior administrator before making significant changes to production systems.

Review Pattern: With the review pattern, you can approve, reject, or edit actions before the agent executes them. This is particularly important for sensitive operations where human judgment is required.

Implementation: When AgentWatch wants to perform potentially impactful actions such as modifying AWS resources, adjusting scaling policies, or changing alarm thresholds, it presents its proposed action to you through Slack, along with relevant context and reasoning. You can then approve the action to proceed, reject it entirely, or edit the parameters before execution.These HITL patterns provide multiple benefits for your team. They lower implementation risks by making sure appropriate human oversight at critical moments. The patterns mimic natural human communication found in engineering teams, making adoption intuitive. Over time, the agent learns from your feedback, continuously improving its decision-making.

Now let’s explore the technical architecture that brings these capabilities to life.
Architecture and implementation
AgentWatch implements a scheduled monitoring system that autonomously collects and summarizes AWS infrastructure data every 15 minutes. This monitoring approach uses AI-powered agents to gather current system information and deliver structured status reports through Slack notifications.

Figure 1: AgentWatch Architecture Diagram

The AgentWatch monitoring cycle begins with Amazon EventBridge triggering an AWS Lambda function every 15 minutes through a cron-based rule. This Lambda function authenticates with Amazon Cognito using Open Authorization 2.0 (OAuth 2.0) client credentials to obtain a bearer token, then calls AgentCore Runtime with the monitoring prompt. AgentCore instantiates a LangChain agent a framework for building applications powered by language models that can use tools and maintain conversation context with access to seven specialized monitoring tools for AWS infrastructure equipped with specialized CloudWatch monitoring tools that systematically collect infrastructure data, including dashboards, log groups, service logs, error patterns, alarm statuses, and cross-account metrics, providing comprehensive visibility across your AWS environment.
After data collection completes, the LangChain agent sends the aggregated CloudWatch data to Amazon Bedrock’s Claude Sonnet model, which processes and transforms raw monitoring information into contextual, human-readable insights. The intelligent summary flows back through the agent to AgentCore Runtime and returns to the Lambda function, which formats the analysis into structured Slack blocks with organized sections for log analysis and alarm status. AgentWatch then delivers the formatted monitoring report to your designated Slack channel via webhook, providing your team with regular, automated health updates about your AWS infrastructure directly in your collaboration workspace these monitoring tasks occur without manual intervention.
We built AgentWatch as a LangChain agent with access to seven specialized monitoring tools for AWS infrastructure. The agent uses the Amazon Bedrock Claude model for natural language understanding and can analyze CloudWatch dashboards, fetch logs, examine alarms, and perform cross-account monitoring. The architecture follows a hybrid ambient model with both scheduled monitoring and on-demand interaction capabilities.Using the LLM’s natural language understanding, AgentWatch analyzes complex AWS monitoring scenarios. It determines which tool combinations provide monitoring coverage, then generates human-readable reports with actionable insights. The agent maintains conversation context across interactions, which supports follow-up questions and progressive refinement of monitoring strategies.
Deploy the agent on AgentCore Runtime, provides a secure, serverless, and purpose-built hosting environment for running AI agents at scale. AgentCore Runtime supports multiple agent frameworks and model providers. After you deploy the agent, it becomes available as an HTTP endpoint that you can call programmatically. AgentCore Identity handles authentication using OAuth 2 with Cognito as the identity provider, though you can use other OpenID Connect (OIDC)-compliant identity providers (IdPs).
The deployment infrastructure consists of three main components working together. First, a Lambda function serves as the orchestration layer. It authenticates with Cognito to obtain bearer tokens, calls the AgentCore Runtime endpoint with appropriate prompts, and formats responses for Slack.

@app.entrypoint
def agent_handler(payload: Dict[str, Any]) -> str:
# Extract prompt and session context
user_prompt = payload.get(“prompt”)
thread_id = payload.get(“session_id”, “default-session”)
# Invoke agent with conversation memory
result = monitoring_agent.invoke(
{“messages”: [{“role”: “user”, “content”: user_prompt}]},
{“configurable”: {“thread_id”: thread_id}}
)
return result[‘messages’][-1].content

Second, EventBridge provides scheduled invocation capability through a rule configured to trigger every 15 minutes. When the rule fires, Lambda uses a pre-configured monitoring prompt requesting summaries of CloudWatch alarms, critical issues, and resource health.
Third, an Amazon API Gateway exposes the Lambda function as an HTTP endpoint that integrates with a Slack app through slash commands. Your questions typed in Slack route to API Gateway, which triggers Lambda with your question as the prompt.
This dual-trigger architecture allows AgentWatch to operate in two modes. In scheduled mode, the agent runs autonomously every 15 minutes, proactively monitoring AWS infrastructure and posting reports to keep your team informed without manual intervention. In on-demand mode, you can ask specific questions through Slack and receive immediate responses, allowing for interactive troubleshooting and investigation when needed.
Now let’s see how these capabilities work in practice with real-world examples.
AgentWatch in action
The following screenshots demonstrate both operational modes of AgentWatch.
Scheduled Monitoring Reports: Every 15 minutes, AgentWatch automatically generates and posts monitoring reports to Slack, providing your team with continuous visibility into AWS infrastructure health.

Figure 2: Scheduled monitoring report in Slack showing CloudWatch alarms, resource health, and critical issues

On-demand Interaction: You can ask specific questions through Slack slash commands to investigate issues or get real-time information. The agent processes your question and provides detailed, context-aware responses based on current AWS infrastructure state.

Figure 3: User asking a specific question via Slack slash command and receiving a detailed response

Beyond these operational examples, AgentWatch delivers broader value across your organization.
Use cases and benefits
AgentWatch delivers value across multiple operational scenarios. The solution identifies potential issues before they impact your users by continuously analyzing CloudWatch metrics, logs, and alarms across your AWS infrastructure. This proactive approach reduces operational overhead, so your team spends less time on routine monitoring tasks while maintaining visibility into system health through automated reports and intelligent alerting.
The Slack integration enhances team collaboration by supporting natural language queries and discussions about infrastructure issues, improving communication between your development and operations teams. For enterprise environments, cross-account support allows large organizations to monitor distributed AWS infrastructures from a centralized intelligent agent
Getting started
To get started with AgentWatch, visit the GitHub repository for complete deployment instructions and implementation details.
Prerequisites
Before deploying AgentWatch, verify that you have an AWS account with CloudWatch, Lambda, and EventBridge permissions. You will need a Cognito User Pool configured for OAuth 2.0 authentication and a Slack Workspace where you have app creation permissions. For local development and customization, Python 3.11 or later is required.
Quick setup
Use the following commands for quick steup.

Configure Identity Provider

python idp_setup/setup_cognito.py

Deploy Agent to AgentCore Runtime

# Install the latest AgentCore CLI
npm install -g @aws/agentcore
# Create an AgentCore project and bring your existing agent code
agentcore create –name AgentWatch –no-agent
agentcore add agent \
–name AgentWatch \
–type byo \
–code-location . \
–entrypoint ambient_agent.py \
–language Python

# Deploy to AgentCore Runtime
agentcore deploy

Deploy Infrastructure.

cd deployment
./deploy.sh

Configure Slack Integration – Update your Slack app with the API Gateway endpoint from deployment output.

The deployment script automates the entire setup process. It configures your identity provider (Cognito), deploys the agent to AgentCore Runtime, and sets up the Lambda function, EventBridge rule, and API Gateway. After completion, the script provides the Slack webhook URL that you will need for your app configuration.
Testing the deployment

Scheduled Monitoring: AgentWatch automatically posts reports every 15 minutes.
On-Demand Queries: Use Slack slash commands for specific questions:

/ask What is the status of my CloudWatch alarms?
/ask Show me recent errors in my Lambda functions
/ask Analyze log patterns for the last hour

Post deployment, make sure your implementation follows these security and operational best practices.
Security and best practices
AgentWatch implements multiple security layers to protect your infrastructure. OAuth 2.0 with Cognito supports secure API access, while AWS Identity and Access Management (IAM) role assumption provides fine-grained cross-account permissions. AgentCore Runtime adds enterprise-grade security and compliance capabilities. For operational safety, the HITL patterns help prevent inappropriate autonomous actions. The agent’s conversation memory maintains context while respecting session boundaries, and logging provides audit trails and troubleshooting capabilities.
Extending AgentWatch
The ambient agent architecture that we’ve built for monitoring can be extended to other operational domains.

Cost optimization: Add tools for analyzing spending patterns and recommending optimization opportunities.
Security monitoring: Integrate with AWS Security Hub and Amazon GuardDuty for threat detection.
Compliance reporting: Automate compliance checks across AWS Config and AWS CloudTrail.
Performance analysis: Enhance with application performance monitoring and optimization recommendations.

Conclusion
In this post, we showed you how AgentWatch improves infrastructure monitoring by combining autonomous operations with appropriate human oversight. You saw how the solution performs infrastructure checks every 15 minutes, delivers actionable reports to Slack, and responds to natural language queries about your AWS environment. The three human-in-the-loop patterns i.e. notify, question, and review make sure you remain informed and in control while benefiting from continuous intelligent monitoring.
The architecture uses AWS Managed Services (AMS) and Amazon Bedrock AgentCore Runtime to provide a scalable, secure foundation for ambient agent deployment. You can apply this approach beyond AWS monitoring to other domains requiring continuous observation with selective human involvement, including cost optimization, security monitoring, compliance reporting, and performance analysis.
As AI agents become more sophisticated, ambient architectures like AgentWatch will help you operate more efficiently while maintaining the human judgment necessary for critical infrastructure decisions. To get started with AgentWatch, visit AgentWatch – GitHub the for complete deployment instructions and implementation details.

About the authors

Sriharsha M Sis a Principal Gen AI specialist solution architect in the Strategic Specialist team at Amazon Web Services. He works with strategic AWS customers who are taking advantage of AI/ML to solve complex business problems. He provides technical guidance and design advice to foundational model science and agentic AI applications at scale. His expertise spans application hardware accelerators, architecture, big data, analytics and machine learning.

Shweta Keshavanarayana is a Senior Technical Customer Solutions Manager at AWS. She works with AWS Strategic Customers and helps them in their cloud migration, AI adoption, and modernization journeys. Beyond her professional life, she volunteers as a team manager for her son’s U9 cricket team, while also mentoring women in tech and serving the local community.

Madhur Prashant is a former Applied Generative AI Architect at Amazon Web Services. He is passionate about the intersection of human thinking and Agentic AI. His interests lie in generative AI, cognitive science and specifically building solutions that are helpful and harmless, and most of all optimal for customers. Outside of work, he loves doing yoga, hiking, spending time with his twin sister, and playing the guitar.

Neha Thakur is a Solutions Architect at Amazon Web Services, working as both a generalist across the breadth of AWS services and a specialist in AI/ML. She helps customers solve complex business challenges by leveraging AWS AI/ML services. Neha is a core team member of Women-in-AI at AWS UK, where she contributes to diversity and inclusion initiatives in the technology sector and mentors others in their professional development.

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Generate single title from this title I tested a 4TB quantum-resistant USB drive – but you don’t have to spend $3000 for this much security in 100 -150 characters. And it must return only title i dont want any extra information or introductory text with title e.g: ” Here is a single title:”

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Apricorn Aegis Secure Key 3

pros and cons

Pros

  • Quantum-resistant encryption
  • Totally platform independent
  • Very tough, crush-resistant, and IP68 rated

Cons

  • Very expensive
  • Overkill in terms of capacity for most users.

more buying choices

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Losing a laptop is inconvenient, but usually the worst that happens is some finger-pointing and a bit of awkward explaining. Losing an unencrypted USB drive containing client data can trigger a breach notification under HIPAA or GDPR, even if nobody ever plugs it in.

And that’s why I recommend hardware-encrypted storage drives. They don’t stop you from losing the drive, but they do make the data on it worthless.

Also: Why I still recommend Synology’s DS225+ NAS – even if it can’t replace your cloud storage

Apricorn is a manufacturer of encrypted storage drives that I’ve been reviewing — and using personally — for years, including the 3NX, the 3Z, and other Aegis keys. Last week, it released a 4TB version of its Aegis Secure Key 3, the highest-capacity hardware-encrypted USB drive of its kind. 

And this isn’t some bulky thing that sits on your desk. No, this is a quantum-resistant hardware-encrypted flash drive that you can slip into your pocket.

What is ‘quantum-resistant hardware encryption’?

Modern encryption has moved well ahead of letter substitution codes. Imagine a combination lock, but rather than three wheels with 0 to 9 on them, as you have on a locker or toolshed offering 1,000 possibilities, this has roughly the same number of possibilities as atoms in the universe (a mind-bogglingly massive number: a 1 followed by 77 zeros).  

These are not numbers anyone will be able to guess at — or brute-force — even with a powerful computer at their disposal.

Also: I ditched Google Drive for my own self-hosted storage – and I wish I’d done it sooner

Well, not yet…

The problem is that computers are getting faster, and quantum computers could boost performance to the point that something considered secure today could be trivial to crack down the line. So, if you’re holding data with a long confidentiality shelf life (like health records, company data, or the plans for the Death Star), you want any encrypted data that might have leaked into the wild to stay encrypted for as long as possible.

“Quantum-resistant” encryption protects against the threat posed by “harvest now, decrypt later,” and that’s what the AES-256 XTS encryption used by Apricorn provides. 

How Apricorn protects against real-world attacks

But while we tend to think of breaking encryption as involving big, fancy supercomputers, most attacks are far simpler, relying on things like default passwords, people using weak ones, or keypads revealing the PIN because the often-used keys show signs of wear.

Yes, high security can fail because of something that simple.

The drive works perfectly on USB-C Macs using a thord-party USB-C-to-USB-A adapter.

The drive works perfectly on USB-C-equipped Macs with a third-party USB-C-to-USB-A adapter.

Adrian Kingsley-Hughes/ZDNET

Apricorn has this covered. From shipping the drive with no default passwords or PIN codes, to blocking short PINs and passcodes, to building the keypad from a wear-resistant polymer.

Think you can break open the drive and get it to spill its secrets? The drive has been packed full of epoxy resin to prevent tampering.

Unlike a lot of encrypted flash drives, this one is easy to use and self-contained. There’s no app or executable you have to run. You plug it into a USB port, press a button, enter the passcode, and you’re in. And because the drive doesn’t rely on running an app, it’s totally platform-independent, so you can use it on any device that supports USB storage.

Also: The best external hard drives: Expert tested and reviewed

The drive features anti-brute-force protection that wipes the drive if someone tries to guess the passcode, and a built-in unattended auto-lock that secures the drive if you walk away or become distracted.

For an added level of security, there’s also the ability to set a self-destruct PIN to quickly wipe the drive of its contents, yet make it seem like it is fully working.

Apricorn says the drive meets and exceeds FIPS 140-3 Level 3 requirements and has submitted it to NIST for formal validation.

It’s also IP68 rated against dust and water ingress (completely dustproof and protected against prolonged water immersion), and built from tough, extruded aluminum, so it’s drop-resistant and crushproof to 6,500 pounds. 

How it compares to iStorage and Kingston

Apricorn isn’t the only player in this market, and the Aegis Secure Key 3 has competition from the likes of the iStorage datAshur PRO+C and Kingston IronKey.

And what’s interesting is that when you compare these two against the Aegis Secure Key 3, they’re very similar — until you look at maximum capacity.

 

Apricorn Aegis Secure Key 3

iStorage datAshur PRO+C

Kingston IronKey Keypad 200

Min/Max capacity

16GB/4TB

32GB/512GB

8GB/512GB

Encryption

AES-256 XTS, hardware-based

AES-256 XTS, hardware-based

AES-256 XTS, hardware-based

FIPS status

Submitted to NIST CMVP for 140-3 Level 3 validation (pending, not yet certified)

datAshur PRO+C: FIPS 140-3 Level 3 validated

FIPS 140-3 Level 3 validated

Keypad

Yes

Yes

Yes

IP rating

IP68

IP68

IP68

Entry price

~$169 (16GB tier)

~$96 (32GB)

~$75 (8GB)

Top-tier price (max capacity)

~$3,000 (4TB)

~$259 (512GB)

~$389 (512GB)

Apricorn’s real differentiator isn’t the drive’s security — AES-256 XTS offers the same quantum resistance across all devices — it’s capacity. Nobody else makes a hardware-encrypted USB flash drive above 512GB, so the 4TB Aegis Secure Key 3 has no direct competitor at that tier.

Who needs 4TB for pocketable storage?

Not a lot of people do, and this is exactly why Apricorn makes the Aegis Secure Key 3 in nine capacities, going from 16GB to 4TB.

Also: This coin-sized flash drive doubles my laptop’s storage space – and it’s cheaper than you think

However, as Apricorn points out, government agencies, defense contractors, healthcare providers, financial institutions, legal professionals, and digital forensic investigators may find themselves handling sensitive information. There are also all sorts of data that shouldn’t travel across networks and require an air-gapped transfer method.

ZDNET’s buying advice

A 4TB flash drive that uses quantum-resistant cryptography isn’t cheap, and the Aegis Secure Key 3 certainly isn’t cheap — given its $3,000 price tag. But at the lower end of the capacity spectrum, prices start at $169, making this kind of encryption within reach of most.

On paper, the Aegis Secure Key 3 has quite a fair bit of competition, but not when it comes to capacity. If you want a hardware-encrypted flash drive that’s bigger than 512GB, you’ll be going with Apricorn.

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Generate single title from this title Data Science • AI • Advanced Analytics in 100 -150 characters. And it must return only title i dont want any extra information or introductory text with title e.g: ” Here is a single title:”

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With all the scientific advancements in recent years, just finding planets outside our solar system is not challenging. However, finding out what they’re actually like is much more difficult. In a new groundbreaking study, Harvard University researchers report the strongest evidence yet that the rocky exoplanet LHS 1140 b has an atmosphere, making it one of the most interesting planets discovered in the AI era. 

The team reached that conclusion by analyzing an incredibly weak signal hidden in telescope observations. They combined multiple observations with detailed computer models to determine that the signal came from helium escaping the planet’s atmosphere, providing what researchers say is the strongest evidence so far that a rocky planet in the habitable zone has retained an atmosphere.

Why does having an atmosphere matter so much? The discovery doesn’t mean LHS 1140 b is habitable or that it contains life. Instead, it gives scientists another reason to keep studying the planet. Future observations could reveal what the atmosphere is made of, whether it contains water vapor or other important gases, and how similar (or different) it is from Earth’s atmosphere. A discovery of this magnitude can go a long way in helping scientists better understand which distant planets are the best candidates for future exploration.

“An atmosphere is essential for a planet to support life as we know it,” said lead author Collin Cherubim, who recently earned his Ph.D. in Earth and Planetary Sciences from Harvard University. “This is the first time anyone has found an atmosphere on a rocky planet in the habitable zone of another star.”

Now let’s get to how they actually did it, and what role did data and AI play in it. After all, detecting an atmosphere around a planet that is 48 light-years away is far from straightforward. The signal researchers were looking for was not just weak, it was also buried within vast amounts of telescope data. The scientists had to go through repeated observations to first extract the data and then use advanced data analysis techniques to distinguish a real atmospheric signature from noise. 

(Shutterstock/Alones)

AI wasn’t responsible for making the discovery on its own, but it formed part of the broader computational toolkit. It helped researchers analyze the data and validate their findings. 

“Twenty years ago we wondered whether other terrestrial-type planets even existed,” said Robin Wordsworth, Gordon McKay Professor of Environmental Science and Engineering and Professor of Earth and Planetary Sciences at Harvard and one of Cherubim’s dissertation advisors. “Then we learned they’re common, and found some in the habitable zone. The next question was whether any of them had managed to keep an atmosphere. Now we know at least one has.”

One reason this discovery has attracted so much attention is that LHS 1140 b wasn’t chosen at random. Astronomers have been interested in the planet for years. Ever since it was discovered in 2017, it quickly became one of the most promising rocky planets outside our solar system. 

One of the primary reasons for that is that it lies in what astronomers refer to as a habitable zone – the region around a star where the temperature is just right for liquid water to exist on a planet’s surface. Other important factors were its rocky planet, and not a gas giant like Jupiter. It is also close enough to study than many other exoplanets. 

Last year, observations from the James Webb Space Telescope (JWST) suggested it could even be a water-rich world with a dense atmosphere rather than a bare rocky planet, making it an even more attractive target for follow-up studies.

(Shutterstock/Gorodenkoff)

The new study takes that work a step further. Instead of simply suggesting an atmosphere might exist, researchers found direct evidence that one does. Interestingly, the team detected helium escaping from the planet during observations in 2024, but the same escaping helium wasn’t seen in observations taken in 2025. Rather than weakening the discovery, researchers say this suggests the atmosphere itself changes over time as it interacts with radiation from the host star.

The researchers also observed another planet in the same system, known as LHS 1140 c. That planet showed no signs of an atmosphere. Seeing two neighboring planets produce completely different results gives scientists another opportunity to understand why some planets manage to keep their atmospheres for billions of years while others lose them. 

Having two neighboring planets orbiting the same star gives astronomers a rare opportunity to compare why one appears to have held onto its atmosphere while the other may have lost it. 

As astronomers prepare for more detailed observations with the JWST over the next few years, LHS 1140 b will likely serve as a test case for future atmospheric studies. What scientists learn from this planet could shape how they search for and study potentially habitable rocky worlds for years to come.

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